Q‌‍‍‍‌‍‍‌‌‍‍‍‌‍‍‍‍‌‍‍uestion: What is the clinical significance of the interaction between P2Y12 inhibitors and proton pump inhibitors? Note: Your drug information response should not be longer than 1 page in length! Background: Paragraph 1: Background information about disease state topic and medication (including Pharmacologic category, brand name, route of administration, dosing, renal or hepatic adjustments, summary of warnings/precautions, etc). Paragraph 2: Cite and discuss the specific guideline recommendations and level of evidence (when available) • You may want to start by saying something like According to the 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults, in patients with…..(recommendation). Please insert the guideline that you used. o Guidelines can include published recommendations from national organizations, such as the Centers for Disease Control (CDC) • Provided that you gave enough background about the disease state and medications before this point you may want to discuss why this is. Was the reason this medication was recommended because of its effect on morbidity and mortality, cardiovascular disease, potential side effects, cost, etc? This information is typically found and elaborated on within the guidelines, textbooks, and/or ‌‍‍‍‌‍‍‌‌‍‍‍‌‍‍‍‍‌‍‍UptoDate. Also discuss the level of evidence behind the recommendation. Paragraph 3: Primary literature to support the guideline recommendation • Summarize the primary article(s) that was used to support the recommendation. This would include including the objective of the study, patient population studied, what were the two groups (control and intervention group), methods and type of study, primary outcome, results and conclusion of the study. This can mostly be pulled from the abstract of the study. However, I do recommend reading the entire article as parts of the introduction, discussion and conclusion may provide you with more information to include into other sections in the drug information response. Recommendation/Conclusion: Paragraph 4: Conclusion (Overall Recommendation Summary) • Provide answer to drug information question that is adequately supported by literature • If drug information request requires a treatment recommendation, be sure to include a specific therapeutic recommendation (medication, dose, route, frequency, duration, monitoring, etc.) References: • Cite in AMA format numerical order with superscripts in the answer • Use multiple references to answer drug information question – including treatment guidelines, tertiary literature (., treatment guidelines), primary literature, etc. • At least one reference should be‌‍‍‍‌‍‍‌‌‍‍‍‌‍‍‍‍‌‍‍ primary literature